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US 49: Enters from Mississippi near Helena, running north to Piggott.
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US 59: Travels from Texarkana to the Oklahoma state line west of Acorn.
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US 61: Runs from the Tennessee state line near West Memphis to the Missouri state line near Blytheville.
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US 62: Crosses the state from the Oklahoma state line to the Missouri state line near St. Francis.
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US 63: Extends from Junction City to the Missouri state line near Mammoth Spring.
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US 64: Spans from the Oklahoma state line near Fort Smith to the Tennessee state line near Memphis.
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US 65: Runs from the Louisiana state line south of Eudora to the Missouri state line north of Burlington.
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US 67: Connects Texarkana to the Missouri state line north of Corning.
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US 70: Travels from the Oklahoma state line near De Queen to the Tennessee state line near Memphis.
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US 71: Extends from the Louisiana state line near Ida to the Missouri state line north of Bella Vista.
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US 79: Runs from the Louisiana state line near Haynesville to the Tennessee state line near Memphis.
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US 82: Crosses southern Arkansas from the Texas state line near Texarkana to the Mississippi state line near Lake Village.
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US 165: Travels from the Louisiana state line near Wilmot to North Little Rock.
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US 167: Extends from the Louisiana state line near Junction City to the Missouri state line near Batesville.
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US 270: Runs from the Oklahoma state line near Acorn to White Hall.
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US 278: Crosses the state from the Mississippi River near Greenville, Mississippi, to the Oklahoma state line near Wickes.
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US 371: Travels from the Louisiana state line near Springhill to De Queen.
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US 412: Spans from the Oklahoma state line near Siloam Springs to the Missouri state line near Paragould.
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